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Article

ERK1 and ERK2 activate CCAAAT/enhancer-binding protein-beta-dependent gene transcription in response to interferon-gamma.

The Journal of biological chemistry - 5 Jan 2001

Hu J, Roy S K, Shapiro P S, Rodig S R, Reddy S P, Platanias L C, Schreiber R D, Kalvakolanu D V

Abstract excerpt

Interferons (IFNs) regulate the expression of a number of cellular genes by activating the JAK-STAT pathway. We have recently discovered that CCAAAT/enhancer-binding protein-beta (C/EBP-beta) induces gene transcription through a novel IFN response element called the gamma-IFN-activated transcript...

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Source

Identifiers

PMID: 10995751
DOI: 10.1074/jbc.M004885200

Genes

EBP
JAK1
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10995751-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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