Article
Fine mapping of genetic susceptibility loci for melanoma reveals a mixture of single variant and multiple variant regions.
International journal of cancer - 15 Mar 2015
Barrett Jennifer H, Taylor John C, Bright Chloe, Harland Mark, Dunning Alison M, Akslen Lars A, Andresen Per A, Avril Marie-Françoise, Azizi Esther, Bianchi Scarrà Giovanna, Brossard Myriam, Brown Kevin M, Dębniak Tadeusz, Elder David E, Friedman Eitan, Ghiorzo Paola, Gillanders Elizabeth M, Gruis Nelleke A, Hansson Johan, Helsing Per, Hočevar Marko, Höiom Veronica, Ingvar Christian, Landi Maria Teresa, Lang Julie, Lathrop G Mark, Lubiński Jan, Mackie Rona M, Molven Anders, Novaković Srdjan, Olsson Håkan, Puig Susana, Puig-Butille Joan Anton, van der Stoep Nienke, van Doorn Remco, van Workum Wilbert, Goldstein Alisa M, Kanetsky Peter A, Pharoah Paul D P, Demenais Florence, Hayward Nicholas K, Newton Bishop Julia A, Bishop D Timothy, Iles Mark M
Abstract excerpt
At least 17 genomic regions are established as harboring melanoma susceptibility variants, in most instances with genome-wide levels of significance and replication in independent samples. Based on genome-wide single nucleotide polymorphism (SNP) data augmented by imputation to the 1,000 Genomes reference panel, we have fine mapped these regions in over 5,000 individuals with melanoma (mainly from the GenoMEL...
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