Article
Analysis of gender differences in genetic risk: association of TNFAIP3 polymorphism with male childhood-onset systemic lupus erythematosus in the Japanese population.
PloS one - 1 Jan 2013
Kadota Keisuke, Mori Masaaki, Yanagimachi Masakatsu, Miyamae Takako, Hara Takuma, Kanetaka Taichi, Nozawa Tomo, Kikuchi Masako, Hara Ryoki, Imagawa Tomoyuki, Kaneko Tetsuji, Yokota Shumpei
Abstract excerpt
BACKGROUND: Systemic lupus erythematosus (SLE) is a systemic multisystem autoimmune disorder influenced by genetic background and environmental factors. Our aim here was to replicate findings of associations between 7 of the implicated single nucleotide polymorphisms (SNPs) in IRF5, BLK, STAT4, TNFAIP3, SPP1, TNIP1 and ETS1 genes with susceptibility to childhood-onset SLE in the Japanese population. In...
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