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Article

A crosstalk between the Smad and JNK signaling in the TGF-β-induced epithelial-mesenchymal transition in rat peritoneal mesothelial cells.

PloS one - 1 Jan 2012

Liu Qinghua, Zhang Yu, Mao Haiping, Chen Wei, Luo Ning, Zhou Qin, Chen Wenfang, Yu Xueqing

Abstract excerpt

Transforming growth factor β (TGF-β) induces the process of epithelial-mesenchymal transition (EMT) through the Smad and JNK signaling. However, it is unclear how these pathways interact in the TGF-β1-induced EMT in rat peritoneal mesothelial cells (RPMCs). Here, we show that inhibition of JNK activation by introducing the dominant-negative JNK1 gene attenuates the TGF-β1-down-regulated E-cadherin expression, and...

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Source

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Identifiers

PMID: 22384127
DOI: 10.1371/journal.pone.0032009
PMCID: PMC3288060

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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