Article
Cardiovascular malformations with normal smooth muscle differentiation in neural crest-specific type II TGFbeta receptor (Tgfbr2) mutant mice.
Developmental biology - 15 Jan 2006
Choudhary Bibha, Ito Yoshihiro, Makita Takako, Sasaki Tomoyo, Chai Yang, Sucov Henry M
Abstract excerpt
Previous studies have demonstrated that TGFbeta induces a smooth muscle fate in primary neural crest cells in culture. By crossing a conditional allele of the type II TGFbeta receptor with the neural crest-specific Wnt1cre transgene, we have addressed the in vivo requirement for TGFbeta signaling in smooth muscle specification and differentiation. We find that elimination of the TGFbeta receptor does not alter...
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