Article
Validation of the performance of a comprehensive genotyping assay panel of single nucleotide polymorphisms in drug metabolism enzyme genes.
Human mutation - 1 May 2008
Welch Robert A, Lazaruk Katherine, Haque Kashif A, Hyland Fiona, Xiao Nianqing, Wronka Loni, Burdett Laura, Chanock Stephen J, Ingber Daniel, De La Vega Francisco M, Yeager Meredith
Abstract excerpt
A class of genes, known as drug metabolism enzymes (DMEs) are responsible for the metabolism and transport of drugs and other xenobiotics. Variation in DME genes most likely accounts for a proportion of the variability in drug response in humans, and may contribute to complex diseases such as cancer (Nebert DW, Dieter MZ. Pharmacology 2000;61:124-135). To date, assessing the extent of this variation has proven...
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