Article
Investigation of the C242T polymorphism of NAD(P)H oxidase p22 phox gene and ischaemic heart disease using family-based association methods.
Clinical science (London, England : 1979) - 1 Dec 2003
Spence M S, McGlinchey P G, Patterson C C, Allen A R, Murphy G, Bayraktutan U, Fogarty D G, Evans A E, McKeown P P
Abstract excerpt
Ischaemic heart disease is a complex phenotype arising from the interaction of genetic and environmental factors. Excessive production of reactive oxygen species leading to endothelial dysfunction is believed to be important in the pathogenesis of ischaemic heart disease. The NAD(P)H oxidase system generates superoxide anions in vascular cells; however, the role of the C242T polymorphism of the NAD(P)H oxidase...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.