Article

Hyperactive mTORC1/4EBP1 Signaling Dysregulates Proteostasis and Accelerates Cardiac Aging

2024-05-14

Abstract excerpt

The mechanistic target of rapamycin complex 1 (mTORC1) has a major impact on aging by regulation of proteostasis. It is well established that mTORC1 signaling is hyperactivated with aging and age-related diseases. Previous studies have shown that partial inhibition of mTOR signaling by rapamycin reverses the age-related decline in cardiac function and structure in old mice. However, the downstream signaling pathwa...

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Identifiers and source

Literature Corpus work: c35fd330-6558-53d5-aa67-872074f86cf2
DOI: 10.1101/2024.05.13.594044

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