Article
COOH-terminal deletion of HBx gene is a frequent event in HBV-associated hepatocellular carcinoma
1 Jan 2008
Abstract excerpt
AIM: To investigate the hepatitis B virus (HBV)x gene (HBx) state in the tissues of HBV-related hepatocellular carcinoma (HCC) in Chinese patients and whether there were particular HBx mutations. METHODS: HBx gene was amplified and direct sequencing was used in genomic DNA samples from 20 HCC and corresponding non-cancerous liver tissues from HBsAg-positive patients. HBV DNA integration and HBx deleted mutation...
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