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Article

Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning.

Science translational medicine - 7 Dec 2016

Azarov Ivan, Wang Ling, Rose Jason J, Xu Qinzi, Huang Xueyin N, Belanger Andrea, Wang Ying, Guo Lanping, Liu Chen, Ucer Kamil B, McTiernan Charles F, O'Donnell Christopher P, Shiva Sruti, Tejero Jesús, Kim-Shapiro Daniel B, Gladwin Mark T

Abstract excerpt

Carbon monoxide (CO) is a leading cause of poisoning deaths worldwide, with no available antidotal therapy. We introduce a potential treatment paradigm for CO poisoning, based on near-irreversible binding of CO by an engineered human neuroglobin (Ngb). Ngb is a six-coordinate hemoprotein, with the heme iron coordinated by two histidine residues. We mutated the distal histidine to glutamine (H64Q) and substituted...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27928027
DOI: 10.1126/scitranslmed.aah6571
PMCID: PMC5206801

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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