Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sensitivity to epidermal growth factor receptor inhibitor requires E-cadherin expression in urothelial carcinoma cells.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2008

Black Peter C, Brown Gordon A, Inamoto Teruo, Shrader Marissa, Arora Ameeta, Siefker-Radtke Arlene O, Adam Liana, Theodorescu Dan, Wu Xifeng, Munsell Mark F, Bar-Eli Menashe, McConkey David J, Dinney Colin P N

Abstract excerpt

PURPOSE: Epidermal growth factor receptor (EGFR) is an attractive target for the treatment of urothelial carcinoma, but a clinical response can be expected in only a small proportion of patients. The aim of this study was to define molecular markers of response to cetuximab therapy in a panel of urothelial carcinoma cell lines. EXPERIMENTAL DESIGN: Eleven cell lines were investigated for antiproliferative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal, Humanized
Share to Cadherins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Transitional Cell

Share to Cetuximab

Share to Mice, Nude

Share to Neoplasm Invasiveness

Share to NIH 3T3 Cells

Share to Urinary Bladder Neoplasms

Source

Identifiers

PMID: 18316572
DOI: 10.1158/1078-0432.CCR-07-1593

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Sensitivity to epidermal growth factor receptor inhibitor requires E-cadherin expression in urothelial carcinoma cells.PMID 18316572Read ↗

Loss of homotypic cell adhesion by epithelial-mesenchymal transition or mutation limits sensitivity to epidermal growth factor receptor inhibition.Semantic proximity Read ↗

Relevance of MET activation and genetic alterations of KRAS and E-cadherin for cetuximab sensitivity of gastric cancer cell lines.Semantic proximity Read ↗

Biomarkers for predicting response to tyrosine kinase inhibitors in drug-sensitive and drug-resistant human bladder cancer cells.Semantic proximity Read ↗

Delta-crystallin enhancer binding factor 1 controls the epithelial to mesenchymal transition phenotype and resistance to the epidermal growth factor receptor inhibitor erlotinib in human head and neck squamous cell carcinoma lines.Semantic proximity Read ↗

Prognostic significance of epithelial-mesenchymal transition phenotypes in upper urinary tract urothelial carcinoma.Semantic proximity Read ↗

Differential Regulation of Growth-Promoting Signalling Pathways by E-CadherinSemantic proximity Read ↗

Cadherin switching dictates the biology of transitional cell carcinoma of the bladder: <i>ex vivo</i> and <i>in vitro</i> studiesSemantic proximity Read ↗

EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinomaSemantic proximity Read ↗

Effect of wild-type and mutant E-cadherin on cell proliferation and responsiveness to the chemotherapeutic agents cisplatin, etoposide, and 5-fluorouracil.Semantic proximity Read ↗

Alteration of the E-cadherin/β-catenin complex predicts poor response to epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) treatment.Semantic proximity Read ↗

ALTERED gamma-CATENIN EXPRESSION CORRELATES WITH POOR SURVIVAL IN PATIENTS WITH BLADDER CANCERSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.