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Article

Relevance of MET activation and genetic alterations of KRAS and E-cadherin for cetuximab sensitivity of gastric cancer cell lines.

Journal of cancer research and clinical oncology - 1 May 2012

Heindl Stefan, Eggenstein Evelyn, Keller Simone, Kneissl Julia, Keller Gisela, Mutze Kathrin, Rauser Sandra, Gasteiger Georg, Drexler Ingo, Hapfelmeier Alexander, Höfler Heinz, Luber Birgit

Abstract excerpt

PURPOSE: The therapeutic activity of the epidermal growth factor receptor (EGFR)-directed monoclonal antibody cetuximab in gastric cancer is currently being investigated. Reliable biomarkers for the identification of patients who are likely to benefit from the treatment are not available. The aim...

Read the complete abstract on PubMed

Topics

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Share to Antibodies, Monoclonal, Humanized
Share to Cadherins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cetuximab

Share to Cisplatin

Share to Fluorescent Antibody Technique, Indirect

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Share to Proto-Oncogene Proteins c-met

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Source

Identifiers

PMID: 22290393
DOI: 10.1007/s00432-011-1128-4

Genes

EGFR
MET
KRAS
CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22290393-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Relevance of MET activation and genetic alterations of KRAS and E-cadherin for cetuximab sensitivity of gastric cancer cell lines.PMID 22290393Read ↗

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