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Article

Relevance of MET activation and genetic alterations of KRAS and E-cadherin for cetuximab sensitivity of gastric cancer cell lines.

Journal of cancer research and clinical oncology - 1 May 2012

Heindl Stefan, Eggenstein Evelyn, Keller Simone, Kneissl Julia, Keller Gisela, Mutze Kathrin, Rauser Sandra, Gasteiger Georg, Drexler Ingo, Hapfelmeier Alexander, Höfler Heinz, Luber Birgit

Abstract excerpt

PURPOSE: The therapeutic activity of the epidermal growth factor receptor (EGFR)-directed monoclonal antibody cetuximab in gastric cancer is currently being investigated. Reliable biomarkers for the identification of patients who are likely to benefit from the treatment are not available. The aim of the study was to examine the drug sensitivity of five gastric cancer cell lines towards cetuximab as a single agent...

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Share to Antibodies, Monoclonal, Humanized
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cetuximab

Share to Cisplatin

Share to Fluorescent Antibody Technique, Indirect

Share to Fluorouracil

Share to Proto-Oncogene Proteins c-met

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Source

Identifiers

PMID: 22290393
DOI: 10.1007/s00432-011-1128-4

Genes

EGFR
MET
KRAS
CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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