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Cadherin switching dictates the biology of transitional cell carcinoma of the bladder: <i>ex vivo</i> and <i>in vitro</i> studies

27 Feb 2008

Abstract excerpt

Bladder cancer is the fifth most common malignancy in the UK. Clinically, the most important process in determining prognosis is the development of invasion, initially of the lamina propria and then beyond as these transitional cell carcinomas (TCCs) progress from stage pT1 to stages T2+. Cadherins and catenins are the main mediators of cell-cell interactions in epithelial tissues, and loss of membranous...

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PMID: 18393367
DOI: 10.1002/path.2346

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