Article
Autoproteolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1 mucin.
Nature structural & molecular biology - 1 Jan 2006
Macao Bertil, Johansson Denny G A, Hansson Gunnar C, Härd Torleif
Abstract excerpt
The single cell layer of the lungs and the gastrointestinal tract is protected by the mucus formed by large glycoproteins called mucins. Transmembrane mucins typically contain 110-residue SEA domains located next to the membrane. These domains undergo post-translational cleavage between glycine and serine in a characteristic GSVVV sequence, but the two peptides remain tightly associated. We show that the SEA...
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