Article
YraP Contributes to Cell Envelope Integrity and Virulence of Salmonella enterica Serovar Typhimurium.
Infection and immunity - 1 Nov 2018
Morris Faye C, Wells Timothy J, Bryant Jack A, Schager Anna E, Sevastsyanovich Yanina R, Squire Derrick J P, Marshall Jennifer, Isom Georgia L, Rooke Jessica, Maderbocus Riyaz, Knowles Timothy J, Overduin Michael, Rossiter Amanda E, Cunningham Adam F, Henderson Ian R
Abstract excerpt
Mutations in σE-regulated lipoproteins have previously been shown to impact bacterial viability under conditions of stress and during in vivo infection. YraP is conserved across a number of Gram-negative pathogens, including Neisseria meningitidis, where the homolog is a component of the Bexsero meningococcal group B vaccine. Investigations using laboratory-adapted Escherichia coli K-12 have shown that yraP...
Topics
- Animals
- Anti-Bacterial Agents
- Bacterial Outer Membrane Proteins
- Cell Line
- Disease Models, Animal
- Epithelial Cells
- Humans
- Lipoproteins
- Macrophages