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Article

Epigenetic dysregulation of the Wnt signalling pathway in chronic lymphocytic leukaemia

2 Sept 2008

Abstract excerpt

BACKGROUND: Wnt signalling has recently been implicated in the pathogenesis of cancer. METHODS: This study investigated the activity of Wnt signalling in peripheral blood chronic lymphocytic leukaemia (CLL) lymphocytes, and the methylation status of seven soluble Wnt antagonist genes, including WIF1, DKK3, APC, SFRP1, SFRP2, SFRP4 and SFRP5, by using methylation-specific PCR in the peripheral blood CLL...

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Identifiers

PMID: 18765431
DOI: 10.1136/jcp.2008.060152

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