Article
Transcription factor 7-like 2 (TCF7L2) variant is associated with familial breast cancer risk: a case-control study.
BMC cancer - 17 Nov 2006
Burwinkel Barbara, Shanmugam Kalai S, Hemminki Kari, Meindl Alfons, Schmutzler Rita K, Sutter Christian, Wappenschmidt Barbara, Kiechle Marion, Bartram Claus R, Frank Bernd
Abstract excerpt
BACKGROUND: The transcription factor 7-like 2 (TCF7L2) is a critical component of the Wnt/beta-catenin pathway. Aberrant TCF7L2 expression modifies Wnt signaling and mediates oncogenic effects through the upregulation of c-MYC and cyclin D. Genetic alterations in TCF7L2 may therefore affect cancer risk. Recently, TCF7L2 variants, including the microsatellite marker DG10S478 and the nearly perfectly linked SNP...
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