Article
Fitness of isogenic colony morphology variants of Pseudomonas aeruginosa in murine airway infection.
PloS one - 27 Feb 2008
Rakhimova Elza, Munder Antje, Wiehlmann Lutz, Bredenbruch Florian, Tümmler Burkhard
Abstract excerpt
Chronic lung infections with Pseudomonas aeruginosa are associated with the diversification of the persisting clone into niche specialists and morphotypes, a phenomenon called 'dissociative behaviour'. To explore the potential of P. aeruginosa to change its morphotype by single step loss-of-function mutagenesis, a signature-tagged mini-Tn5 plasposon library of the cystic fibrosis airway isolate TBCF10839 was...
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