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Article

Sub-inhibitory concentrations of some antibiotics can drive diversification of Pseudomonas aeruginosa populations in artificial sputum medium.

BMC microbiology - 23 Jul 2013

Wright Elli A, Fothergill Joanne L, Paterson Steve, Brockhurst Michael A, Winstanley Craig

Abstract excerpt

BACKGROUND: Pseudomonas aeruginosa populations within the cystic fibrosis lung exhibit extensive phenotypic and genetic diversification. The resultant population diversity is thought to be crucial to the persistence of infection and may underpin the progression of disease. However, because cystic fibrosis lungs represent ecologically complex and hostile environments, the selective forces driving this...

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Identifiers

PMID: 23879797
DOI: 10.1186/1471-2180-13-170
PMCID: PMC3726342

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