Article
Associations between serum anti-CCP antibody, rheumatoid factor levels and HLA-DR4 expression in Hungarian patients with rheumatoid arthritis.
The Israel Medical Association journal : IMAJ - 1 Jan 2008
Kapitány Anikó, Szabó Zoltán, Lakos Gabriella, Aleksza Magdolna, Végvári Anikó, Soós Lilla, Karányi Zsolt, Sipka Sándor, Szegedi Gyula, Szekanecz Zoltán
Abstract excerpt
BACKGROUND: The presence of anti-cyclic citrullinated peptide autoantibody is highly specific for rheumatoid arthritis. Certain HLA-DR4 (HLA-DRB1*04) alleles, also known as the "shared epitope," are associated with increased susceptibility to RA. In addition, these alleles may also have relevance for disease outcome. Anti-CCP antibody positivity has been associated with the presence of HLA-DR4 alleles in patients...
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