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Article

Liver-specific expression of p53-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Apr 2008

Chen Li-Je, Hsu Chia-Chun, Hong Jiann-Ruey, Jou Luen-Kuang, Tseng Hung-Chia, Wu Jen-Leih, Liou Yih-Cherng, Her Guor Mour

Abstract excerpt

Tumorigenesis requires inactivation of the p53 tumor suppressor pathway, likely involving the negative regulator Mdm2 protein. To analyze the possible roles of Mdm2 in oncogenesis and other functions during zebrafish hepatogenesis, we generated transgenic zebrafish by liver-specific Mdm2 over-expression utilizing a fusion between genes encoding GFP and mdm2, GFP::Mdm2. Over-expression of GFP::Mdm2 in the...

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PMID: 18297734
DOI: 10.1002/dvdy.21477

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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