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Article

Cirrhotic livers reveal genetic changes in the MDM2-P14ARF system of cell cycle regulators.

British journal of cancer - 22 Apr 2002

Schlott T, Scharf J G, Gorzel C, Middel P, Spring H

Abstract excerpt

The genesis of hepatocellular carcinoma is promoted by changes in the regulatory MDM2-P14ARF system. The incidence of such changes has to date not been analysed in non-tumourous livers showing regenerative proliferation. In the present study, 24 cirrhotic livers of alcohol-, autoimmue disorder- or HCV-caused genesis were screened for MDM2-P14ARF alterations at the level of protein, DNA and mRNA. Using confocal...

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-mdm2

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Source

Open in PubMed Open full text

Identifiers

PMID: 11953887
DOI: 10.1038/sj.bjc.6600238
PMCID: PMC2375354

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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