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BMP9-induced osteoblastic differentiation requires functional Notch signaling in mesenchymal stem cells

23 Oct 2018

Abstract excerpt

Mesenchymal stem cells (MSCs) are multipotent progenitors that can differentiate into multiple lineages including osteoblastic lineage. Osteogenic differentiation of MSCs is a cascade that recapitulates most, if not all, of the molecular events occurring during embryonic skeletal development, which is regulated by numerous signaling pathways including bone morphogenetic proteins (BMPs). Through a comprehensive...

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PMID: 30353129
DOI: 10.1038/s41374-018-0087-7

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