Article
VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.
Nature cell biology - 1 Mar 2008
Young Arthur P, Schlisio Susanne, Minamishima Yoji Andrew, Zhang Qing, Li Lianjie, Grisanzio Chiara, Signoretti Sabina, Kaelin William G
Abstract excerpt
Germline von Hippel-Lindau tumour suppressor gene (VHL) mutations cause renal cell carcinomas, haemangioblastomas and phaeochromocytomas in humans. Mutations in VHL also occur in sporadic renal cell carcinomas. The protein encoded by VHL, VHL, is part of the ubiquitin ligase that downregulates the heterodimeric transcription factor Hif under well-oxygenated conditions. Here we show that acute VHL inactivation...
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