Article
Senescence-associated protein p400 is a prognostic marker in renal cell carcinoma.
Oncology reports - 1 Nov 2013
Macher-Goeppinger Stephan, Bermejo Justo Lorenzo, Schirmacher Peter, Pahernik Sascha, Hohenfellner Markus, Roth Wilfried
Abstract excerpt
Mutations of the von Hippel-Lindau (VHL) tumor suppressor gene cause hereditary and sporadic renal cell carcinomas (RCCs). The best characterized function of VHL protein is suppression of the α subunit of hypoxia inducible factor (HIF). Additional VHL functions have been reported, including induction of senescence upon loss of VHL mediated by downregulation of the chromatin remodeling factor p400. Induction of...
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