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Article

Estimation of morbid risk and age at onset with missing information.

American journal of human genetics - 1 Jul 1991

Cupples L A, Risch N, Farrer L A, Myers R H

Abstract excerpt

Investigators of genetic illnesses are currently employing life-table techniques to estimate the lifetime risk of disease and the age-at-onset distribution. This methodology assumes that onset ages are known for affected individuals and that censoring ages are known for unaffected individuals. We extend these methods to incorporate affected individuals with unknown onset ages and unaffected persons with unknown...

Topics

Age Factors
Algorithms
Genetic Diseases, Inborn
Genetic Predisposition to Disease
Humans
Huntington Disease
Likelihood Functions
Pedigree
Risk Factors

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1829582
PMCID: PMC1683228

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1829582-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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