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Article

Molecular evolution of the prostate cancer susceptibility locus RNASEL: evidence for positive selection.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 May 2008

Summers Kyle, Crespi Bernard

Abstract excerpt

Recent research implicates viral infection as a factor that may contribute to the risk of prostate cancer. Allelic variation at the RNASEL locus is associated with the risk of infection by a newly discovered retrovirus called XMRV, and with hereditary risk of prostate cancer. This evidence suggests that the RNASEL locus has undergone antagonistic coevolution with the retrovirus over evolutionary time. If this is...

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Source

Identifiers

PMID: 18295551
DOI: 10.1016/j.meegid.2008.01.004

Genes

RNASEL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular evolution of the prostate cancer susceptibility locus RNASEL: evidence for positive selection.PMID 18295551Read ↗

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Detection of xenotropic murine leukemia virus-related virus in normal and tumor tissue of patients from the southern United States with prostate cancer is dependent on specific polymerase chain reaction conditions.Semantic proximity Read ↗

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