Article
RNASEL mutation screening and association study in Ashkenazi and non-Ashkenazi prostate cancer patients.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 2006
Orr-Urtreger Avi, Bar-Shira Anat, Bercovich Dani, Matarasso Noa, Rozovsky Uri, Rosner Serena, Soloviov Sonya, Rennert Gad, Kadouri Luna, Hubert Ayala, Rennert Hanna, Matzkin Haim
Abstract excerpt
Epidemiologic and genetic studies support the considerable effect of heritable factors on prostate tumorigenesis, although to date, no unequivocal susceptibility gene has been identified. The extensive study of RNASEL in prostate cancer patients worldwide has yielded conflicting results. We reevaluated the role of the RNASEL 471delAAAG Ashkenazi founder mutation in 1,642 Ashkenazi patients with prostate, bladder,...
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