Article
Associations between glucose tolerance, insulin sensitivity and insulin secretion phenotypes and polymorphisms in adiponectin and adiponectin receptor genes in the Quebec Family Study.
Diabetic medicine : a journal of the British Diabetic Association - 1 Apr 2008
Ruchat S-M, Loos R J F, Rankinen T, Vohl M-C, Weisnagel S J, Després J-P, Bouchard C, Pérusse L
Abstract excerpt
AIMS: Studies suggest that adiponectin (APM1) and its receptors 1 and 2 (AdipoR1 and AdipoR2) play an important role in the development of insulin resistance (IR). Our objective was to examine associations between APM1 (+45T>G, +276G>T and -3971A>G), AdipoR1 (-100G>T and -3882T>C) and AdipoR2 (-35361A>G and -1352G>A) genes single-nucleotide polymorphisms (SNPs) and adiponectin plasma levels, indicators of glucose...
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