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Article

CD45 isoform switching precedes the activation-driven death of human thymocytes by apoptosis.

International immunology - 1 Jan 1991

Merkenschlager M, Fisher A G

Abstract excerpt

A recently described chimaeric organ culture system is employed to investigate the effects of antibodies to the CD3 and CD2 cell surface structures on the fate of developing human thymocyte populations. Engagement of CD3 as well as CD2 with reagents that stimulate peripheral human T cell results in the activation-induced death of human thymocytes in organ culture. Death is preceded by a characteristic phenotypic...

Topics

Animals
Antigens, CD
Antigens, Differentiation
Cell Survival
Histocompatibility Antigens
Humans
Leukocyte Common Antigens
Lymphocyte Activation
Mice
Organ Culture Techniques
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

T-Lymphocytes

Thymus Gland

Source

Identifiers

PMID: 1828692
DOI: 10.1093/intimm/3.1.1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1828692-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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