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Article

CD45 isoform switching precedes the activation-driven death of human thymocytes by apoptosis.

International immunology - 1 Jan 1991

Merkenschlager M, Fisher A G

Abstract excerpt

A recently described chimaeric organ culture system is employed to investigate the effects of antibodies to the CD3 and CD2 cell surface structures on the fate of developing human thymocyte populations. Engagement of CD3 as well as CD2 with reagents that stimulate peripheral human T cell results in the activation-induced death of human thymocytes in organ culture. Death is preceded by a characteristic phenotypic...

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Identifiers

PMID: 1828692
DOI: 10.1093/intimm/3.1.1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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