Article
Subpopulations of fetal thymocytes defined by expression of T cell receptor/CD3 and IL-2 receptor. CD3 and IL-2 receptor alpha-chain are expressed on reciprocal cell populations.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 1991
Guy R, Foo-Philips M, Sharrow S O, Hodes R J
Abstract excerpt
The expression of the TCR/CD3 complex and the IL-2R alpha chain (p55) on fetal thymocytes has been analyzed by flow cytometry (FCM). Two-parameter immunofluorescence identified three subpopulations which were respectively IL-2R alpha-/CD3+, IL-2R alpha+/CD3-, or IL-2R alpha-/CD3-; no detectable population of IL-2R alpha+/CD3+ cells was found in unstimulated fetal thymocytes. Fractionation by "panning" and by...
Topics
- Animals
- Antigens, Differentiation, T-Lymphocyte
- CD3 Complex
- Cell Differentiation
- Cell Division
- Fetus
- Fluorescent Antibody Technique
- Lymphocyte Activation
- Lymphokines
- Mice