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Article

Thymic epithelial cells induce Fas-independent activation apoptosis of thymocytes.

Immunology letters - 1 Oct 2001

Sharova N I, Dzutsev A K, Litvina M M, Pleskovskaya G N, Kharchenko T Y, Yarilin A A

Abstract excerpt

Co-cultivation of human thymocytes with homologous thymic epithelial cells (TEC) resulted in apoptosis of thymocytes and increase of CD25 expression. TEC supernatant also induced these effects. Fraction of apoptotic cells was enriched by CD69+ cells but not by CD95+ cells. Thymocytes of mice MRL-lpr/lpr bearing mutant form of gene Fas were sensitive to apoptosis induction in co-culture with TEC in the same degree...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11578696
DOI: 10.1016/s0165-2478(01)00253-x

Genes

TEC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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