Article
A genome-wide linkage scan for low spinal bone mineral density in a single extended family confirms linkage to 1p36.3.
European journal of human genetics : EJHG - 1 Aug 2008
Willaert Andy, Van Pottelbergh Inge, Zmierczak Hans, Goemaere Stefan, Kaufman Jean-Marc, De Paepe Anne, Coucke Paul
Abstract excerpt
Osteoporotic fractures are an increasing cause of mortality and morbidity in ageing populations. A major risk determinant for these fractures is bone mineral density (BMD). Variation on BMD is thought, on the basis of twin and family studies, to be subject to a large amount of genetic variation and it has been hypothesised that this may be due to the influence of multiple genes. However, in families showing...
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