Article
Association of a polymorphism of the transforming growth factor-beta1 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Oct 1998
Yamada Y, Miyauchi A, Goto J, Takagi Y, Okuizumi H, Kanematsu M, Hase M, Takai H, Harada A, Ikeda K
Abstract excerpt
Transforming growth factor-beta (TGF-beta) is both abundant in bone and an important regulator of bone metabolism. A T-->C transition at nucleotide 29 in the signal sequence region of the TGF-beta1 gene results in a Leu-->Pro substitution at amino acid position 10. The possible association of thi...
Topics
- Adult
- Aged
- Amino Acid Substitution
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Japan
- Leucine
- Middle Aged
- Osteoporosis
- Polymorphism, Genetic
- Postmenopause
- Proline