Article
Association of polymorphisms of the transforming growth factor-beta1 gene with genetic susceptibility to osteoporosis.
Pharmacogenetics - 1 Dec 2001
Yamada Y
Abstract excerpt
Osteoporosis exhibits a substantial genetic component. Although polymorphisms of a variety of genes have been associated with bone mineral density and genetic susceptibility to osteoporosis, the genes responsible for these traits have not been definitively identified. We have shown that a T869-->C polymorphism of the transforming growth factor-beta1 gene, which results in a Leu-->Pro substitution at amino acid...
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