Article
Tests of linkage and/or association of TGF-beta1 and COL1A1 genes with bone mass.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA - 1 Jan 2005
Long Ji-Rong, Liu Peng-Yuan, Lu Yan, Dvornyk Volodymyr, Xiong Dong-Hai, Zhao Lan-Juan, Deng Hong-Wen
Abstract excerpt
Transforming growth factor beta 1 (TGF-beta1) is involved in bone metabolism and collagen type I alpha 1 (COL1A1) is the most abundant protein of bone matrix. Both have been considered as candidate genes for osteoporosis. In this study, we employed the transmission disequilibrium test (TDT) to examine the relationship between each of the two genes with bone mineral density (BMD) and bone mineral content (BMC) at...
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