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Article

Telomerase expression in lung preneoplasia and neoplasia

20 Feb 2007

Abstract excerpt

Telomeres are specialized structures at eukaryotic chromosomes ends, which role is to prevent them from degradation, end to-end fusion and rearrangement. However, they shorten after each cellular division because of an incomplete DNA replication, acting in normal somatic cells as a mitotic clock for permanent proliferation arrest or senescence entry. Short telomeres are perceived as damaged DNA leading to p53/ATM...

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PMID: 17311257
DOI: 10.1002/ijc.22473

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