Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Finding Needles in the Haystack: Strategies for Uncovering Noncoding Regulatory Variants.

Annual review of genetics - 27 Nov 2023

Chen You, Paramo Mauricio I, Zhang Yingying, Yao Li, Shah Sagar R, Jin Yiyang, Zhang Junke, Pan Xiuqi, Yu Haiyuan

Abstract excerpt

Despite accumulating evidence implicating noncoding variants in human diseases, unraveling their functionality remains a significant challenge. Systematic annotations of the regulatory landscape and the growth of sequence variant data sets have fueled the development of tools and methods to identify causal noncoding variants and evaluate their regulatory effects. Here, we review the latest advances in the field...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Predisposition to Disease
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 37562413
DOI: 10.1146/annurev-genet-030723-120717

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Finding Needles in the Haystack: Strategies for Uncovering Noncoding Regulatory Variants.PMID 37562413Read ↗

Challenges and progress in interpretation of non-coding genetic variants associated with human disease.Semantic proximity Read ↗

Exploring noncoding variants in genetic diseases: from detection to functional insights.Semantic proximity Read ↗

NCAD v1.0: a database for non-coding variant annotation and interpretation.Semantic proximity Read ↗

Interpreting noncoding genetic variation in complex traits and human disease.Semantic proximity Read ↗

Exploring the function of genetic variants in the non-coding genomic regions: approaches for identifying human regulatory variants affecting gene expression.Semantic proximity Read ↗

Principles and methods of in-silico prioritization of non-coding regulatory variants.Semantic proximity Read ↗

The Role of Noncoding Variants in Heritable Disease.Semantic proximity Read ↗

Functional annotation of noncoding sequence variants.Semantic proximity Read ↗

Demystifying non-coding GWAS variants: an overview of computational tools and methods.Semantic proximity Read ↗

Computational Assessment of the Regulation-Modulating Potential for Noncoding VariantsSemantic proximity Read ↗

Classification of non-coding variants with high pathogenic impact.Semantic proximity Read ↗

Regulatory variation and evolution: implications for disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.