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Article

Association of genetic variation in the transforming growth factor beta-1 gene with serum levels and risk of colorectal neoplasia.

Cancer research - 15 Feb 2008

Saltzman Barbara S, Yamamoto Jennifer F, Decker Robert, Yokochi Lance, Theriault Andre G, Vogt Thomas M, Le Marchand Loïc

Abstract excerpt

In the normal intestinal epithelium transforming growth factor beta-1 (TGFbeta-1) acts as a growth inhibitor, but in malignant cells it may act as a tumor promoter. However, only limited information is available on genetic variation in the TGFB1 gene and its relationship to circulating levels and risk of colorectal cancer. To characterize associations of genetic variation [tagging single-nucleotide polymorphisms...

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Source

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Identifiers

PMID: 18281501
DOI: 10.1158/0008-5472.CAN-07-2144
PMCID: PMC4545251

Genes

TGFB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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