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Article

Allele-specific nuclear positioning of the monoallelically expressed astrocyte marker GFAP.

Genes & development - 15 Feb 2008

Takizawa Takumi, Gudla Prabhakar R, Guo Liying, Lockett Stephan, Misteli Tom

Abstract excerpt

Chromosomes and genes are nonrandomly arranged within the mammalian cell nucleus. However, the functional significance of nuclear positioning in gene expression is unclear. Here we directly probed the relationship between nuclear positioning and gene activity by comparing the location of the active and inactive copies of a monoallelically expressed gene in single cell nuclei. We demonstrate that the...

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Identifiers

PMID: 18281462
DOI: 10.1101/gad.1634608
PMCID: PMC2238670

Genes

GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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