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The association of myeloperoxidase promoter polymorphism with carotid atherosclerosis is abolished in patients with type 2 diabetes.

Clinical biochemistry - 1 May 2008

Mäkelä Riikka, Loimaala Antti, Nenonen Arja, Mercuri Michele, Vuori Ilkka, Huhtala Heini, Oja Pekka, Bond Gene, Koivula Timo, Lehtimäki Terho

Abstract excerpt

OBJECTIVES: Type 2 diabetes mellitus (DM) enhances the development of atherosclerosis and reduces the activity of the oxidative myeloperoxidase (MPO) enzyme. MPO gene has a functional promoter polymorphism -463G/A which leads to high- (GG) and low-expression (AG, AA) genotypes. DESIGN AND METHODS: We studied the association of MPO polymorphism with carotid artery intima-media thickness (IMT) in 198 randomly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 18280811
DOI: 10.1016/j.clinbiochem.2008.01.017

Genes

MPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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