Article
Genetic variants in IRF6 and the risk of facial clefts: single-marker and haplotype-based analyses in a population-based case-control study of facial clefts in Norway.
Genetic epidemiology - 1 Jul 2008
Jugessur Astanand, Rahimov Fedik, Lie Rolv T, Wilcox Allen J, Gjessing Håkon K, Nilsen Roy M, Nguyen Truc Trung, Murray Jeffrey C
Abstract excerpt
Mutations in the gene encoding interferon regulatory factor 6 (IRF6) underlie a common form of syndromic clefting known as Van der Woude syndrome. Lip pits and missing teeth are the only additional features distinguishing the syndrome from isolated clefts. Van der Woude syndrome, therefore, provides an excellent model for studying the isolated forms of clefting. From a population-based case-control study of...
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