Article
Interferon regulatory factor-6: a gene predisposing to isolated cleft lip with or without cleft palate in the Belgian population.
European journal of human genetics : EJHG - 1 Nov 2005
Ghassibé Michella, Bayet Benedicte, Revencu Nicole, Verellen-Dumoulin Christine, Gillerot Yves, Vanwijck Romain, Vikkula Miikka
Abstract excerpt
Cleft lip with or without cleft palate is the most frequent craniofacial malformation in humans ( approximately 1/700). Its etiology is multifactorial; some are a result of a genetic mutation, while others may be due to environmental factors, with genetic predisposition playing an important role. The prevalence varies widely between populations and the mode of inheritance remains controversial. The interferon...
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