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Article

miRNA-130a regulates C/EBP-ε expression during granulopoiesis

8 Jan 2014

Abstract excerpt

CCAAT/enhancer binding protein-ε (C/EBP-ε) is considered a master transcription factor regulating terminal neutrophil maturation. It is essential for expression of secondary granule proteins, but it also regulates proliferation, cell cycle, and maturation during granulopoiesis. Cebpe(-/-) mice have incomplete granulocytic differentiation and increased sensitivity toward bacterial infections. The amount of C/EBP-ε...

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PMID: 24398327
DOI: 10.1182/blood-2013-08-523233

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