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Article

Excess FGF-7 in corneal epithelium causes corneal intraepithelial neoplasia in young mice and epithelium hyperplasia in adult mice.

The American journal of pathology - 1 Mar 2008

Chikama Taiichiro, Liu Chia-Yang, Meij Johanna T A, Hayashi Yasuhito, Wang I-Jong, Yang Liu, Nishida Teruo, Kao Winston W Y

Abstract excerpt

We hypothesized that human ocular surface squamous neoplasia (OSSN) may result from the continuous growth stimulation of corneal epithelial progenitor cells. In the present study, we analyzed the effects of excess fibroblast growth factor-7 (FGF-7) on both the proliferation and differentiation of...

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Identifiers

PMID: 18276784
DOI: 10.2353/ajpath.2008.070897
PMCID: PMC2258268

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18276784-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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