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Article

PAX6 dosage effects on corneal development, growth, and wound healing.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 May 2008

Dorà Natalie, Ou Jingxing, Kucerova Romana, Parisi Ida, West John D, Collinson J Martin

Abstract excerpt

The requirement for correct dosage of the transcription factor Pax6 during corneal growth and development was investigated using the Pax6-overexpressing (PAX77) transgenic mouse. Transgenics had a microcornea phenotype due to failure of postnatal growth, associated with reduction in the number of cells layers in the corneal epithelium. Cell cycle progression was monitored using bromodeoxyuridine, p63, cyclin E,...

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Share to Cornea
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelium

Share to Lens, Crystalline

Share to Mice, Inbred CBA

Share to Paired Box Transcription Factors

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Source

Open in PubMed Open full text

Identifiers

PMID: 18386822
DOI: 10.1002/dvdy.21528
PMCID: PMC2655055

Genes

PAX6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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