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Article

SMAD4-Dependent Signaling Pathway Involves in the Pathogenesis of TGFBR2-Related CE-like Phenotype.

Cells - 4 Apr 2024

Wang Yen-Chiao, Zolnik Olivia Betty, Liu Chia-Yang

Abstract excerpt

(1) Background: Our previous data indicated that disturbance of the Transforming Growth Factor beta (TGFB) signaling pathway via its Type-2 Receptor (TGFBR2) can cause a Corneal Ectasia (CE)-like phenotype. The purpose of this study is to elucidate whether the SMAD4-dependent signaling pathway is involved in the TGFBR2-related CE-like pathogenesis. (2) Methods: Smad4 was designed to be conditionally knocked out...

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Identifiers

PMID: 38607065
DOI: 10.3390/cells13070626
PMCID: PMC11011447

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