Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

doi:10.1084/jem.173.5.1213

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Article

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

The Journal of experimental medicine - 1 May 1991

Hardy R R, Carmack C E, Shinton S A, Kemp J D, Hayakawa K

Abstract excerpt

We have resolved B220+ IgM- B-lineage cells in mouse bone marrow into four fractions based on differential cell surface expression of determinants recognized by S7 (leukosialin, CD43), BP-1, and 30F1 (heat stable antigen). Functional differences among these fractions can be correlated with Ig gene rearrangement status. The largest fraction, lacking S7, consists of pre-B cells whereas the others, expressing S7,...

Topics

Animals
Antigens, CD
Antigens, Surface
B-Lymphocytes
Base Sequence
Biotin
Bone Marrow
Bone Marrow Cells
Cell Differentiation
Cell Membrane
Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA

Female

Gene Rearrangement, B-Lymphocyte, Heavy Chain

Gene Rearrangement, B-Lymphocyte, Light Chain

Hematopoietic Stem Cells

Immunoglobulin Heavy Chains

Leukosialin

Source

Open in PubMed Open full text

Identifiers

PMID: 1827140
DOI: 10.1084/jem.173.5.1213
PMCID: PMC2118850

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1827140-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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