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Article

IL-7R expression and IL-7 signaling confer a distinct phenotype on developing human B-lineage cells.

Blood - 25 Aug 2011

Nodland Sonja E, Berkowska Magdalena A, Bajer Anna A, Shah Nisha, de Ridder Dick, van Dongen Jacques J M, LeBien Tucker W, van Zelm Menno C

Abstract excerpt

IL-7 is an important cytokine for lymphocyte differentiation. Similar to what occurs in vivo, human CD19⁺ cells developing in human/murine xenogeneic cultures show differential expression of the IL-7 receptor α (IL-7Rα) chain (CD127). We now describe the relationship between CD127 expression/signaling and Ig gene rearrangement. In the present study, < 10% of CD19⁺CD127⁺ and CD19⁺CD127⁻ populations had complete...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain

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Source

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Identifiers

PMID: 21680796
DOI: 10.1182/blood-2010-08-302513
PMCID: PMC3162350

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IGH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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