Article
Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia.
Blood - 1 May 2008
Tomasson Michael H, Xiang Zhifu, Walgren Richard, Zhao Yu, Kasai Yumi, Miner Tracie, Ries Rhonda E, Lubman Olga, Fremont Daved H, McLellan Michael D, Payton Jacqueline E, Westervelt Peter, DiPersio John F, Link Daniel C, Walter Matthew J, Graubert Timothy A, Watson Mark, Baty Jack, Heath Sharon, Shannon William D, Nagarajan Rakesh, Bloomfield Clara D, Mardis Elaine R, Wilson Richard K, Ley Timothy J
Abstract excerpt
Activating mutations in tyrosine kinase (TK) genes (eg, FLT3 and KIT) are found in more than 30% of patients with de novo acute myeloid leukemia (AML); many groups have speculated that mutations in other TK genes may be present in the remaining 70%. We performed high-throughput resequencing of th...
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